Continuous production of chiral 1-phenylethanol through yeast-mediated reduction of acetophenone using a shallow-bed reactor

摘要

Single enantiomers, rather than the racemic mixtures of compounds frequently used toays, are important for production of pharmaceuticals and pharmaceutical intermediates as well as other fine chemicals such as liquid crystals. hanging use of a racemic mixture to that of a single enantiomer is called "racemic switches:. There would be two ways to produce a homochiral alcohol using microorganism as biocatalyst: one is an enantionselective oxidation of racemate and another is an asymmetric reduction of prochiral ketone.