Phosphoserine-Tethered Semi-Dendrimer Films Induce Osteoblast Proliferation and Differentiation on Titanium-Based Substrates

摘要

Dendrimers are hyperbranched polymers forming highly and 3D ordered nanostructures that can be derived from various monomeric units [1]. When the synthesis is performed in solid phase the branching polymer develops a dome-like (semi-sphere) or treelike structure, the semi-dendrimer [1]. Dendrimers and semi-dendrimers can be designed that bear different physico-chemical properties and branching levels (generations, Gn). Both dendrimers and semi-dendrimers offer a unique opportunity to expose functionalities suitable to favour bio-interactions and a nanostructure to control distance and steric specificity. Semi-dendrimers have been developed to maximize cell recognition processes and biomineralisation [2].