Central Venous Catheters Functionalised with Chlorhexidine-Hexametaphosphate Nanoparticles for Prolonged Anti-Biofilm Efficacy

摘要

5 and 50 mM CHX-NPs prevented biofilm formation of MRSA, P. aeruginosa and E. coli. The bactericidal and bacteriostatic effects of CHX-NPs are thought to be mediated by cell membrane disruption. These findings suggest that the incorporation of novel antimicrobial CHX-NPs into a PU CVC may provide a promising new approach to the prevention of catheter-related infections.