Pro-inflammatory Response to Novel Gelatin-based Biomaterials with Tailorable Mechanical Properties in vitro

摘要

These results point out that direct contact between cells and the hydrogels investigated, but not contact to their hydrolytic or enzymatic degradation products, induced inflammatory reactions in the cells. This indicates an impact of the material surface structure. In general, the materials did not induce endothelial cell dysfunction, whereas macrophages showed inflammatory activation.