Simultaneously reconstructing fluorescent yield and lifetime from time-resolved transmittances of a small-animal-sized phantom

摘要

A full three-dimensional, featured-data algorithm for time-domain diffuse fluorescence tomography is presented, which inverts the Laplace-transformed time-domain coupled diffusion equations and employs a pair of real-domain transform-factors to effectively separate the fluorescent yield and lifetime parameters. By use of a multi-channel time-correlation single photon counting system and a normalized Born formulation for the inversion, the proposed scheme is experimentally validated to achieve simultaneous reconstruction of the fluorescent yield and lifetime distributions with a reasonable accuracy.