Antineoplastic Drug Interactions with DNA Modified Gold Piezoclectrodes

摘要

Antineoplastic drugs are highly reactive agents able to disrupt DNA synthesis and DNA repair in both healthy and cancerous cells. The inhibition of most rapidly growing cells, the cancer cells, is the primary aim of the use of antineoplastic drugs in various chemotherapeutic procedures. Successful application of chemotherapy in treatments of different cancers has prompted extensive research studies of the interactions of antineoplastic drugs with DNA, proteins, and enzymes (1-9). Since the application of antineoplastic drugs comes with serious side effects (10-12), such as organ damage (kidney, liver), cardiomyopathy, immunosuppression, cognitive dysfunction, memory loss, and others, the detailed knowledge of all the interactions of antineoplastic drugs in the body and means of screening from the side effects are of great importance. Our interests are focused on the electrochemical properties of antineoplastic drugs and their interactions with DNA immobilized in electrodic films.