Glucose content monitoring with time-of-flight technique in aqueous Intralipid solution imitating human skin: Monte Carlo simulation

摘要

Glucose content monitoring is of great importance today due to a number of people suffering from diabetes. In this paper, laser pulses propagation in a sample of aqueous Intralipid solution with glucose is simulated by Monte Carlo method. Effect of glucose is based on refractive index matching of Intralipid vesicles and surrounding water if glucose is added. Temporal profiles of femtosecond pulses (906 nm) diffusely scattered within a 2-mm thick plain glass cuvette with a skin phantom are registered in backward direction by two fiber-optics detectors 0.30 mm in diameter with numerical apertures of 0.19, 0.29, and 0.39. It is revealed that glucose content within the physiological range (100-500 mg/dl) can be detected because of the effect of glucose on the peak pulse intensity and on the area under the pulse temporal profile (energy of the registered pulse).