DRUG RELEASE CHARACTERISTICS OF SIX MR DOSAGE FORMS OF DILTIAZEM USINGTHE USP 2 APPARATUS ( PADDLE )

摘要

USP Apparatus 2 was used to compare thedissolution behaviour of six modified release (MR)diltiazem 180 mg products available on the openmarket, to evaluate whether they are exchangeable.Release in both 0.05 M phosphate buffer and inbiorelevant media was studied.