COEFFECT OF AQUEOUS SOLUBILITY OF DRUGS AND GLYCOLIDE MONOMER ON INVITRO RELEASE RATES FROM POLY(D,L-LACTIDE-CO-GLYCOLIDE) DISCS ANDPOLYMER DEGRADATION

摘要

The objective of this study was to investigate theeffect of aqueous solubility of model drugs andglycolide monomer (GM) from 50:50 PLGA discs onin vitro release rates and polymer degradation. 5-Flurouracil (5-FU) release was found to be increasingin proportion to drug loading amount with an initialburst for 5 days, while dexamethasone (DEX)showed absolute antithesis release profiles. However,the discs containing GM showed faster release ratesthan control discs (without GM), respectively and didnot show lag periods during in vitro release test dueto GM.