Formation and Degradation of Poly(sebacic anhydride-co-bis-carboxyphenoxyl propane) Microspheres

摘要

In this study, poly(sebacic anhydride) (PSA) and PSACPP(1,3-bis(carboxyphenoxyl)-propane) were micronisedinto microsphere by solvent dispersion, and lipids wereused as the surfactant to stabilize the particle size. Theamount of surfactant used and the concentration of PSA inthe solvent were studied for their effects on the particlesizes and degradation mechanism, in water and phosphatebuffer.