Biodistribution Study of Rifampicin Bound to Poly(butylcyanoacrylate) Nanoparticles

机译：利福平结合在聚（氰基丙烯酸丁酯）纳米粒子上的生物分布研究

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The pharmacokinetics of rifampicin loaded inrnpoly(butylcyanoacrylate) nanoparticles has beenrnstudied after i.v. injection in mice. Application of thernnanoparticles led to significant alterations of thernbiodistribution of rifampicin. Modification of thernsurface of the nanoparticles with poloxamer 407rnallowed considerable increase of the drugrnaccumulation in lungs, which suggests an enhancedrnpotential of this delivery system for the treatment ofrnlung infections, including tuberculosis.

机译：静脉注射后已研究了利福平负载的聚氰基丙烯酸丁酯纳米颗粒的药代动力学。小鼠注射。纳米颗粒的应用导致利福平的生物分布发生重大变化。用泊洛沙姆407修饰纳米颗粒的表面使肺中药物蓄积显着增加，这表明该递送系统用于治疗包括肺结核在内的肺部感染的潜力增强。

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《Controlled Release Society 31st annual meeting transactions: abstracts》|2004年|1-2|共2页
会议地点 Honolulu HI(US)
作者
Svetlana Gelperina; Andrey Budko; Ervand Oganesyan; Olga Maximenko; Ljudmila Vanchugova; Elena Shipulo; Peter Sveshnikov; Evgeniy Severin; Kevin Kisich; Leonid Heifets;
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Institute of Molecular Medicine, Moscow Sechenov Medical Academy, 2/6 B. Pyrogovskaya, Moscow, Russia Research Center of Molecular Diagnostics and Therapy, 8 Sympheropolsky blvd., Moscow, Russia gelperina@mtu-net.ru;

Blokhin Cancer Research Center, Russian Academy of Medical Sciences, 24 Kashirskoye sh., Moscow, Russia;

Institute of Molecular Medicine, Moscow Sechenov Medical Academy, 2/6 B. Pyrogovskaya, Moscow, Russia;

Institute of Molecular Medicine, Moscow Sechenov Medical Academy, 2/6 B. Pyrogovskaya, Moscow, Russia;

Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 24 Leninsky prosp., Moscow,rnRussia;

Russian Mendeleev University of Chemical Engineering, 9 Miusskaya pl., Moscow, Russia;

Research Center of Molecular Diagnostics and Therapy, 8 Sympheropolsky blvd.,;

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Biodistribution Study of Rifampicin Bound to Poly(butylcyanoacrylate) Nanoparticles

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