Cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabineprodrugs

机译：含有亲脂性吉西他滨前药的脂质体的细胞毒性和药代动力学

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Acyl-gemcitabine derivatives have been synthesized andrnencapsulated in liposomes. Stability in plasma of lipophilicrngemcitabine prodrugs have been evaluated.rnPharmacokinetics of N4-stearoyl-gemcitabine andrnliposomes containing N4-stearoyl-gemcitabine have beenrnstudied.

机译：酰基吉西他滨衍生物已经合成并被脂质体包裹。已经评估了亲脂性吉西他滨前药在血浆中的稳定性。研究了N4-硬脂酰基吉西他滨和含有N4-硬脂酰基吉西他滨的脂质体的药代动力学。

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来源
《Controlled Release Society 31st annual meeting transactions: abstracts》|2004年|1-2|共2页
会议地点 Honolulu HI(US)
作者
M.L. Immordino; P. Brusa; S. Arpicco; F. Rocco; L. Catte;
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作者单位

Dipartimento di Scienza e Tecnologia del Farmaco, 10125 Torino, Italy;

Dipartimento di Scienza e Tecnologia del Farmaco, 10125 Torino, Italy;

Dipartimento di Scienza e Tecnologia del Farmaco, 10125 Torino, Italy;

Dipartimento di Scienza e Tecnologia del Farmaco, 10125 Torino, Italy;

Dipartimento di Scienza e Tecnologia del Farmaco, 10125 Torino, Italy luigi.cattel@unito.it;

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原文格式 PDF
正文语种 eng
中图分类
关键词
liposomes; anticancer agents; prodrugs; rnpharmacokinetics;

机译：脂质体抗癌药前药；药物动力学;

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专利

1. Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs [J] . Immordino ML, Brusa P, Rocco F, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2004,第3期

机译：含有亲脂性吉西他滨前药的脂质体的制备，表征，细胞毒性和药代动力学
2. A novel approach to improve the pharmacokinetic properties of 8-chloro-adenosine by the dual combination of lipophilic derivatisation and liposome formulation [J] . JiaoY.-Y., WangX.-Q., LuW.-L., European journal of pharmaceutical sciences . 2013,第1a2期

机译：通过亲脂性衍生化和脂质体制剂的双重结合来改善8-氯腺苷药代动力学特性的新方法
3. Antitumor activity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs. [J] . Brusa P, Immordino ML, Rocco F, Anticancer Research: International Journal of Cancer Research and Treatment . 2007,第1Appa期

机译：含有亲脂性吉西他滨前药的脂质体的抗肿瘤活性和药代动力学。
4. Cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs [C] . Controlled Release Society annual meeting . 2004

机译：含有亲脂性吉西他滨前药的脂质体的细胞毒性和药代动力学
5. Increasing lipophilicity of redox active ruthenium complexes as a means to enhance cytotoxicity and reduce animal toxicity [D] . Alatrash, Nagham 2012

机译：氧化还原活性钌配合物的亲脂性增加，可增强细胞毒性并降低动物毒性
6. Phosphatidylinositol Stabilizes Fluid-Phase Liposomes Loaded with a Melphalan Lipophilic Prodrug [O] . Daria Tretiakova, Irina Le-Deigen, Natalia Onishchenko, 2021

机译：磷脂酰肌醇稳定载有莫酚亲脂前药的流体相脂质体
7. Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes [O] . Chu Chun, Xu Ping, Zhao Haoyue, 2016

机译：表面配体密度对多西他赛负载脂质体的细胞毒性和药代动力学特性的影响
8. Development of a Pharmacokinetic Description of Lipophilic Chemical Transport inMammary Tissues [R] . Moore, B. A. 1994

机译：乳腺组织中亲脂性化学转运的药代动力学描述的开发

Cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabineprodrugs

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