A Novel Strategy to Modify Adenovirus Tropism and Enhance Transgene Delivery to ActivatedVascular Endothelial Cells In Vitro and In Vivo

摘要

To assess the possibilities of retargetingadenovirus to activated endothelial cells, wehave used a novel method for enhancing genedelivery to disease-associated vascularendothelial cells by coupling cell selectivehoming ligands, i.e.,αv integrin-specific RGDpeptide and E-selectin-specific antibody toPEGylated adenovirus.