Complex Therapeutic-Diagnostic Endoscopy with Laser Irradiation and in-Situ Spectrophotometry of Erosive-Ulcerative Impairments of Upper Part of the Gastrointestinal Tract

摘要

Today in the world there are a lot of effective methods to treat different diseases with the use of low-level laser (LLL) radiation. And there are a number of well-known effective noninvasive (nondestructive, in-vivo, in-situ) optical diagnostic techniques, such as a laser fluorescence spectroscopy (LFS), elastic-scattering spectroscopy (ESS), absorption spectroscopy (ABSS), etc. In this paper the first experience of the complex laser-optical therapeutic-diagnostic treatment for the erosive-ulcerative impairements (EUI) of the upper part of the gastrointestinal tract (UPGT) are discussed. The EUI of the UPGT very often have a resistance to a medicamentous therapy and the treatment of that is very difficult in this case. The method of LLL (He-Ne) irradiation through an endoscope has been used to increase the efficiency of general care for such patients. In parallel the ABSS and the LFS have been used through the same endoscope to increase the efficiency of LLL-therapy and to monitor a general process of recovery respectively. The standard biopsy was investigated to estimate the effect of care as well. As it is shown in this paper the in-situ ABSS allows to optimize the LLL treatment parameters for each patient and for each procedure if the laser has effect on a blood circulation in the irradiated zone. In this case the doctor can see the considerable effect and the reduction period of the cure for EUI. Otherwise, the ABSS indicates that there will be no any effect of LLL therapy for such patient and another methods of treatment are needed. The LFS in this case shows the absence of effect during the care course too. On the basis of analysis of the obtained results this paper presents our current understanding of mechanisms of the laser-induced fluorescence diagnostics and LLL therapy effect for EUI of the UPGT. Today this technique has the official approval of the Ministry of Health of Russian Federation.