Intensity-based registration and combined visualization of multimodal brain images for noninvasive epilepsy surgery planning

摘要

To visualize the brain anatomy, seizure focus location and grid and strip electrodes in 3-dimensional space provides improved planning information for focus localization and margin determination pre- and intra-operatively. In this paper, we present an intensity-based registration and combined visualization of MR, CT, or PET brain images to provide both critical functional information and the structural details. In the first part, we propose a registration method to include spatial information by combining mutual information based on image gradient of the images to be registered. In the second part, we describe a visualization method to display the registered images effectively. To fuse the structural detail of the CT and MR of the same patients with the crucial functional information from the PET scans provide important visual effects which allows direct functional to structural correlation and analysis. It also permits the visual validation of the image region of activation through correlation with abnormal pathology and the symptoms exhibited by the patient during seizure.