A non-Gaussian factor analysis approach to transcription Network Component Analysis

摘要

Transcription factor activities (TFAs), rather than expression levels, control gene expression and provide valuable information for investigating TF-gene regulations. Network Component Analysis (NCA) is a model based method to deduce TFAs and TF-gene control strengths from microarray data and a priori TF-gene connectivity data. We modify NCA to model gene expression regulation by non-Gaussian Factor Analysis (NFA), which assumes TFAs independently comes from Gaussian mixture densities. We properly incorporate a priori connectivity and/or sparsity on the mixing matrix of NFA, and derive, under Bayesian Ying-Yang (BYY) learning framework, a BYY-NFA algorithm that can not only uncover the latent TFA profile similar to NCA, but also is capable of automatically shutting off unnecessary connections. Simulation study demonstrates the effectiveness of BYY-NFA, and a preliminary application to two real world data sets shows that BYY-NFA improves NCA for the case when TF-gene connectivity is not available or not reliable, and may provide a preliminary set of candidate TF-gene interactions or double check unreliable connections for experimental verification.