Comparison of adsorption behavior for fibrinogen and albumin on single walled carbon nanotubes nonwoven

摘要

Fibrinogen and albumin are two of the most important plasma proteins that relate to blood coagulation caused by engineered surfaces. In this paper, the adsorption behavior of albumin and fibrinogen on single-walled carbon nanotubes nonwoven (SWNT nonwoven) was investigated through scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), near edge X-ray adsorption fine structure spectroscopy (NEXAFS) and direct enzyme-linked immunosorbent assay (ELISA) respectively. It was concluded that SWNT nonwoven displayed strong adsorption preference of fibrinogen to albumin. In addition, the immune activity of fibrinogen adhered to the SWNT nonwoven surface was found remained and showed a linear response to the concentration in a certain range.