Single use disposable BioSettler removes the dead cells and cell debris selectively to increase the viability percentage of mammalian cells (e.g., CAR-T) during expansion

摘要

Founder & CEO, Sudhin Biopharma Co., USA 1 Current challenge in Kymriah manufacturing for adult cell therapy seems to be the lower viability of CAR-T cells during cell expansion in bioreactor. 2 This problem can be easily solved by a BioSettler, which can selectively remove the dead cells and cell debris from the expanding cell suspension. 3 BioSettler technology, selective removal of dead cells and recycle of live cells, has been proven with mammalian cells in large perfusion bioreactors. 4 Now this technology is available as single use disposable plastic BioSettlers for autologous cell therapy manufacturing applications.