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Effects of ICG concentration on the optical properties of erythrocyte-derived nano-vectors

机译:ICG浓度对源自红细胞的纳米载体光学特性的影响

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摘要

Erythrocyte-based nanoparticle platforms can offer long circulation times not offered by traditional drug delivery methods. We have developed a novel erythrocyte-based nanoparticle doped with indocyanine green (ICG), the only FDA-approved near-infrared chromophore. Here, we report on the absorption and fluorescence emission characteristics of these nanoparticles fabricated using ICG concentrations in the range of 161-323 μM. These nanoparticles may serve as biocompatible optical materials for various clinical imaging and phototherapeutic applications.
机译:基于红细胞的纳米颗粒平台可以提供传统药物输送方法无法提供的长循环时间。我们已经开发了一种新型的基于红血球的纳米颗粒,掺杂了吲哚菁绿(ICG),这是唯一经FDA批准的近红外发色团。在这里,我们报告了使用161-323μM范围内的ICG浓度制备的这些纳米颗粒的吸收和荧光发射特性。这些纳米粒子可以用作各种临床成像和光疗应用的生物相容性光学材料。

著录项

  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者单位

    Department of Bioengineering, University of California, Riverside, Riverside, CA 92521 U.S.A.;

    Department of Bioengineering, University of California, Riverside, Riverside, CA 92521 U.S.A.;

    Department of Bioengineering, University of California, Riverside, Riverside, CA 92521 U.S.A.;

    Department of Bioengineering, University of California, Riverside, Riverside, CA 92521 U.S.A.;

    Department of Biochemistry, University of California, Riverside, Riverside, CA 92521 U.S.A.;

    Department of Bioengineering, University of California, Riverside, Riverside, CA 92521 U.S.A.;

    Department of Bioengineering, University of California, Riverside, Riverside, CA 92521 U.S.A.;

    Beckman Laser Institute Medical Clinic, University of California, Irvine, Irvine, CA 92617 U.S.A.;

    Beckman Laser Institute Medical Clinic, University of California, Irvine, Irvine, CA 92617 U.S.A.;

    Beckman Laser Institute Medical Clinic, University of California, Irvine, Irvine, CA 92617 U.S.A.;

    Department of Bioengineering, University of California, Riverside, Riverside, CA 92521 U.S.A.,Beckman Laser Institute Medical Clinic, University of California, Irvine, Irvine, CA 92617 U.S.A.;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Cancer; dynamic light scattering; fluorescence; indocyanine green; nanoparticle; phototherapy; spectroscopy; theranostic;

    机译:癌症;动态光散射荧光吲哚菁绿;纳米粒子光疗;光谱学善神的;
  • 入库时间 2022-08-26 14:30:57

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