TUMOR TREATMENT EFFICACY BY FRACTIONATED IRRADIATION WITH GENETIC RADIOTHERAPY

摘要

Genetics and radiologic therapies were recently combined to improve the score of cancer treatment. From the standpoint of evaluating an influence of radiotherapy, some useful objective indicators were proposed. TCP, NTCP and EUD are considered as typical instances. Using these reliable indicators, we propose two objective functions to evaluate tumor treatment efficacy by fractionated irradiation with genetic radiotherapy. The transforming probability from a susceptible cell to a impervious cell and the transduced fraction at which the number of viral vector injections is assumed to be a variable are used for the formulation. Some numerical illustrations are given to understand the influence of these parameters.