Design and Dissolution Profiles of Multi-Phase Liquid-Fill Hard-Capsule Formats

摘要

This reports on formulation studies on an encapsulation method which enables presentation of multi-phase products using liquid-fill capsule technology in a double-capsule format. It takes advantage of ease of formulation in providing, in a single dosage unit, differing release phases for a single drug substance or in generating a single dosage unit with multiple drug substance components.