Performance Comparison of Two Delayed Release Coating Systems for Dietary Supplements

摘要

Two delayed release (DR) coating systems were compared on garlic tablets. The first, an aqueous ethylcellulose dispersion and pH dependent pore former-based coating, successfully resisted simulated gastric fluid (SGF) then disintegrated in simulated intestinal fluid (SIF) at initial testing and after accelerated storage. The second, a shellac-based coating, cracked at initial testing and discolored and completely disintegrated in SGF after accelerated storage.