Drug-Eluting Bioresorbable Stent Coatings: Structure - Release Profile Effects

摘要

Highly porous drug-eluting bioresorbable stent coatings were developed and studied. The effects of the) process parameters on the release kinetics of the antiproliferative drugs paclitaxel andFarnesylthiosalicylate (FTS, Salirasib) from the coatings were studied, with reference to the shell morphology and degradation profile. The release of FTS was found to be affected mainly by water uptake and swelling of the coating's structure, while the paclitaxel's release was affected mainly by degradation of the host polymer. The controlled release of the new drug FTS is reported here for the first time.