Release Mechanisms of Antiproliferative Drugs from Novel Bioresorbable Stent Coatings

摘要

Drug-eluting stents significantly reduce the incidence of in-stent restenosis, which was once considered a major adverse outcome of percutanous coronary stent implantation. Localized release of antiproliferative drugs interferes with the pathological proliferation of vascular smooth muscle cells which is the main cause of in-stent restenosis. In cancer therapy, sometimes an integrated therapeutic approach is desired, especially in brain tumors where drug fail to cross the blood brain barrier. In accordance with this concept, a delivery system loaded with antiproliferative drug at tumor resection site will provide a high local concentration of the drug detrimental to malignant cells which may have survived surgery, thus preventing re-growth and metastasis of tumor.