DEVELOPMENT OF BILAYERED BUCCAL TABLET OF DILTIAZEM USING MODIFIED ACRYLATE POLYMER

摘要

Extensive efforts have been focused at developing mucoadhesive drug delivery systems for an efficient control of systemic delivery. An ideal pharmaceutical buccal dosage for sustained or controlled drug delivery would be able to (1) release drug immediately to produce a prompt pharmacological action, and (2) provide a sustained release of enough drug over an extended period of time. Taking into account such requirements, the design of tablet containing an immediate release layer and a controlled release layer was addressed taking Diltiazem (DLZ) as a model drug.