Dual modality fluorescence and reflectance Hyperspectral imaging: principle and applications

摘要

We present the principles and applications of our dual-modality fluorescence and reflectance hyperspectral imaging (DMHSI) system. In this paper we report on background work done using laser induced fluorescence (LIF) by the group in the early detection of esophageal cancer. We then demonstrate the capabilities of our new DMHSI system. The system consists of a laser, endoscope, AOTF, and two cameras coupled with optics and electronics. Preliminary results, performed on mouse tissue, show that the system can delineate normal and malignant tissue regions in real-time.