Synthesis of ~(123)Iiodoanthraquinones as a Radiotracer of Breast Cancer

机译：合成〜（123）I碘蒽醌作为乳腺癌的放射性示踪剂

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We have synthesized and evaluated [~(123)I]anthraquinones as inhibitors of HER-2eu receptor. [~(123)I]anthraquinones is more effective blocking of SK-BR-3 than MCF-7. It has proven that [~(123)I]anthraquinones have a specific activity on HER-2eu overexpressed cell. This preliminary study suggests [~(123)I]anthraquinones are potent breast cancer imaging reagent. The more biological experiments are is on going.

机译：我们已经合成并评估了[〜（123）I]蒽醌作为HER-2 / neu受体的抑制剂。 [〜（123）I]蒽醌比MCF-7更有效地阻断SK-BR-3。已经证明[〜（123）I]蒽醌对HER-2 / neu过表达的细胞具有特定的活性。这项初步研究表明[〜（123）I]蒽醌是有效的乳腺癌显像剂。正在进行更多的生物学实验。

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来源
《8th International Conference on Isotopes 2014》|2014年|214-214|共1页
会议地点 Chicago IL(US)
作者
Jeong Hoon Park; Jun Young Lee; Min Goo Hur; Seung Dae Yang; Sang Wook Kim; Kook Hyun Yu;
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作者单位

Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea;

Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea,Department of Advanced Material Chemistry Dongguk University-Gyeongju, Gyeongju, Republic of Korea;

Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea;

Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea;

Department of Advanced Material Chemistry Dongguk University-Gyeongju, Gyeongju, Republic of Korea;

Department of Chemistry, Dongguk University-Seoul, Seoul, Republic of Korea;

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正文语种 eng
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关键词
Anthraquinone; HER-2eu; ~(123)I; breast cancer;

机译：蒽醌; HER-2 / neu; 〜（123）我;乳腺癌;

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专利

1. Synthesis and in vivo evaluation of both (2R,3R)-[~(123)Ⅰ]- and (2S,3S)--[~(123)Ⅰ]-trans-2-hydroxy-5-((E)-3-(iodo) allyloxy)-3-(4-phenyl-l-piperazinyl) tetralin as SPECT radiotracer [J] . Thaer Assaad, Abdul H. Al Rayyes Nukleonika . 2013,第2期

机译：（2R，3R）-[〜（123）Ⅰ]-和（2S，3S）-[〜（123）Ⅰ] -trans-2-hydroxy-5-（（E）- 3-（碘代烯丙氧基）-3-（4-苯基-1-哌嗪基）四氢萘作为SPECT放射性示踪剂
2. Synthesis, radiolabeling and baboon SPECT imaging of 2 beta-carbomethoxy-3 beta-(3 '- [I-123]iodophenyl)tropane ([I-123]YP256) as a serotonin transporter radiotracer [J] . Bois F, Baldwin RM, Amici L, Nuclear Medicine and Biology . 2008,第1期

机译：合成，放射标记和狒狒SPECT成像作为5-羟色胺转运体示踪剂的2β-羰甲氧基-3β-（3'-[I-123]碘苯基）托烷（[I-123] YP256）
3. Synthesis and Preliminary Evaluation of 1-18FFluoro-1-deoxy-2,5-anhydro-D-mannitol as a PET Radiotracer for Breast Cancer Imaging [J] . Ben Niu, Xiaoan We, Zhijun Ji, 中国化学（英文版） . 2013,第009期

机译：1- 18F氟-1-脱氧-2,5-脱水-D-甘露糖醇作为PET示踪剂在乳腺癌中的合成及初步评价
4. Synthesis of ~(123)Iiodoanthraquinones as a Radiotracer of Breast Cancer [C] . Jeong Hoon Park, Jun Young Lee, Min Goo Hur, International Conference on Isotopes . 2014

机译：〜（123）i碘坦醌作为乳腺癌的放射性机构
5. Approaches toward the asymmetric total synthesis of (+)-pretazettine and the development of [F-18]-fluorocholine as a radiotracer for the detection of human prostate cancer. [D] . Orr, Matthew David. 2003

机译：走向（+）-pretazettine的不对称全合成和[F-18]-氟胆碱作为放射性示踪剂检测人类前列腺癌的方法。
6. Synthesis radiolabeling and baboon SPECT imaging of 2β-carbomethoxy-3β-(3′-123Iiodophenyl)tropane (123IYP256) as a serotonin transporter radiotracer.(123IYP256) a potential serotonin transporter radiotracer) [O] . Frederic Bois, Ronald M. Baldwin, Louis Amici, -1

机译：2β-碳甲氧基-3β-（3-123I碘苯基）托烷（123I YP256）作为5-羟色胺转运蛋白示踪剂的合成放射性标记和狒狒SPECT成像。（123I YP256）潜在的5-羟色胺转运蛋白示踪剂）
7. Synthesis, radiolabeling and baboon SPECT imaging of 2β-carbomethoxy-3β-(3′-123Iiodophenyl)tropane (123IYP256) as a serotonin transporter radiotracer [O] . Frederic Bois, Ronald M. Baldwin, Louis Amici, 2008

机译：2β-碳甲氧基-3β-（3' - 123i碘苯基）稀氧烷（123i YP256）作为血清素转运蛋白放射反射液的合成，放射性标记和狒狒SPECT成像

Synthesis of ~(123)Iiodoanthraquinones as a Radiotracer of Breast Cancer

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