Protein Function-Function Correlation Approach for Protein Functions Prediction

摘要

BackgroundAssigning functions to novel proteins is one of the most important problems in proteomic study, and many methods have been developed to assign functions to an unknown protein. Most of the methods developed to infer protein functions have many parameters, so it hindered these models'applications in practice.Data & MethodsThe computational method we considered, the socalled protein function pair approach, is carried forward from the protein domain pair approaches [1,2], with protein functions substituted for protein domains in the present study. In our formulation, Kim et al. approach is modified by incorporating a randomization procedure in order to assign functionfunction correlation score for a protein function pair,which could facilitate protein function prediction.