MILP Models for the Synthesis of Protein Purification Processes

摘要

The objective of this work is to develop mixed integer linear programming models for the synthesis of protein purification processes. Formulations that are based on convex hull representations are proposed to calculate the minimum number of steps from a set of chromatographic techniques that must achieve a specified purity level and alternatively to maximize purity for a given number of steps. Models are tested in several examples and present time reductions of up to three orders of magnitude when compared to big-M models.