Evolutionary Synthesis of Almost Closed Conservational Processes

摘要

The synthesis of a "hypothetical" metabolic model is shown that follows the pattern of the citrate cycle (Szentgyoergyi - Krebs cycle). This class of problems is characterized by the possible, alternative biochemical pathways, accompanied with incomplete, uncertain knowledge about the important parameters. The model is recognized and identified by a generic simulator collaborating with a genetic algorithm. The investigated problem is isomorphic with many synthesis tasks, where good solutions have to be selected from amongst the possible, alternative production routes, considering the prescribed rates of the input and output flows between the given system and the environment. Consequently, based on the experiences obtained from the behavior of the natural systems, the notion of the Almost Closed Conservational Processes (ACCP) has been introduced.