On the Optimization of Drug Delivery Devices

摘要

This work presents a novel optimization approach to achieve desired release rates in drug delivery devices using laminated layers. First, a mathematical model is presented to describe the drug release between successive layers laminated together to form matrices with different initial concentrations, drug diffusivities and thickness of each layer. First, an analytical-based optimization approach is performed and results compared with relevant work from the literature. Then, a formal optimal control approach is employed to determine the optimal initial concentration in the layers, along with their thickness and diffusivities, in order to achieve a drug release profile as close to required profile (e.g. constants release) as possible for all times.