Enhanced Surface Bioactivity o/Nanostructured CP-Ti Substrates Processed by Sever Plastic Deformation

摘要

Circulating mesenchymal stem cells (MSC) are known to migrate to various organs to repaired injured tissues. Similarly, circulating bone marrow-derived mesenchymal stem cells can attach to an implant surface, differentiate into bone-forming cells and eventually osteointegrate with the prosthesis. However, bacterial infection following orthopedic surgeries can cause to decrease in the success rate of the implant. Ideal osteocompatible biomaterials should allow good and tight cell attachment, support cell viability and proliferation, promote new bone mineral deposition and simultaneously should inhibit bacterial adhesion. In recent years, the development of ultra-fine grained materials has gained increased interest due to the possibility of obtaining improved bulk and surface properties compared with conventional coarse-grained materials [1,2]. In this study, the effect of the grain size of polycrystalline titanium substrates on cell attachment and bacterial adhesion are investigated. Moreover, the cytotoxic effects of Ti substrates and the ability of hydroxyapatite formation on their surfaces in a simulated body fluid (SBF) are evaluated.