Synthesis and Characterization of a Novel pH-sensitive Nanocarrier for Targeted Drug Delivery

摘要

Over the last recent years, polymeric pH-sensitive polymers have become popular carriers for drug delivery. In particular, the possibility to assemble copolymers with specific and controlled chemical properties allowed obtaining carriers with the desired properties in terms of geometry, hydrophilicity, pH sensitivity and release kinetic. Combining a monomer containing pH-sensitive functionalities with a hydrophilic cross-linking agent, it is possible to obtain polymeric networks that swell in water in a defined range of pH. Also, the introduction of polyethylene glycol), that was found to be able to escape trapping by