Embedded drug delivery controller for cancer chemotherapy under treatment constrains

摘要

Chemotherapy is one of the essential treatment methods for cancer patients. This paper presents a new embedded fuzzy logic control scheme of cancer chemotherapy drug delivery system. The developed controller is capable of achieving targeted drug concentrations at tumor tissues to minimize number of cancerous cells, considering therapeutic constraints; namely maximum allowed levels of both drug infusion dose and drug-dose toxicity. This study has been successfully validated using hardware-in-the-loop simulation technique, based on a mathematical model of patient chemotherapy response and Arduino Mega microcontrollers. Compared to previous studies, the results of embedded drug infusion controller showed that the smallest value of remaining cancerous cells is 8.34, the toxic level of injected drug does not exceed the maximum value of clinical constraint at 100 mg/ml/day, and the best performance index of cancer chemotherapy is 25.51 at the end of treatment time. Therefore, the embedded closed-loop controller in this study presents potentially a good upgrade option for clinical drug delivery systems to enhance the performance of intravenous cancer chemotherapy procedures.