Predicting protein complexes via the integration of multiple biological information

摘要

Protein complexes are a cornerstone of many biological processes and together they form various types of molecular machinery that perform a vast array of biological functions. An increase in the amount of protein-protein interaction (PPI) data enables a number of computational methods for predicting protein complexes. There are a mass of algorithms detecting complexes only consider the PPI data. However, the PPI data from high-throughout techniques is flooded with false interactions. In fact, the insufficiency of the PPI data significantly lowers the accuracy of these methods.