Increased Posterior Cingulate, Medial Frontal and Decreased Temporal Regional Homogeneity in Depressed Mothers A resting-state functional magnetic resonance study

摘要

Objective :To explore the neural pathophysiology of postpartum depression through analyzing fMRI regional homogeneity in postpartum depressed mothers during resting state. Methods :10 depressed mothers and 11 healthy mothers were recruited and underwent functional MRI scanning during resting state. Results : Compared with healthy mothers ,the depressed mothers showed significantly increased posterior cingulate , medial frontal and decreased temporal gyrus regional homogeneity .Conclusions :The results suggest that abnormal neural activities existed in depressed mothers and which may play an important role in psychopathology of postpartum depression .