Antioxidant Activity of Albumin Binding Salphen Schiff-base Cobalt Complexes

摘要

1.Introduction Schiff-base metal complexes have been investigated as effective scavengers of ROSs, acting as antioxidants[1] However, many Schiff-base metal complexes are insoluble, which limited their application. Serum albumins are the major soluble proteins in the circulatory system. The most outstanding property of albumins is their ability to bind reversibly endogenous and exogenous compounds[2]. Here, Salphen Schiff base Co complexes was bound into BSA, which afforded water soluble biopolymer supported Salphen Schiff base metal complexes. Their activities for scavenging the free radical were investigated.