Thrombectomy Aspiration Device model based on the blood clots platelet composition and altherome plaque existence by using the Bond Graph technique

摘要

The World Health Organization estimate that 17 million people die of cardiovascular disease, particularly heart attacks and strokes, every year; coronary heart disease kills more than 7 million and strokes kill nearly 6 million people, occurring mostly in developing countries. Consequently stroke is one of the major causes of mortality world-wide. Most strokes are caused by a blood clot that occludes an artery in the cerebral circulation and the process concerning the removal of this obstruction involves catheterisation. Some studies concerning the analysis, design and optimization of one experimental device developed in the UK - GPTAD - has been analyzed by the authors in other papers, but this model includes a more realistic blood clot -wall adhesion force, introducing and analyzing the different and necessary parameters and changes into the model to make it more realistic. Once fully developed, the GPTAD may provide a means of clot removal from vessels in the human arterial system e.g. the cerebral vessels. The modelling that we present in this paper, taking into account the catheter, the probe, artery, blood clot and adhesion forces, may assist with the optimisation of the design of the GPTAD probe . In the model used for the simulation both mechanical and hydraulic aspects have been considered with the purpose of combining the effect of the fluid-blood transmission for the different sections of the vein, altherome plaque and the catheter.