中国人强直性脊柱炎患者髋关节病变的meta分析

摘要

目的：分析中国人强直性脊柱炎髋关节病变的危险因素. 方法：电子检索中国人强直性脊柱炎髋关节病变的危险因素的相关文献并进行meta分析. 结果：7篇病例对照试验纳入,涉及病人数1384例,合并结果分别为年龄SMD=-0.37,95％CI(-1.16,0.41),P=0.35;发病年龄SMD=-1.09,95％CI(-1.57,-0.60),P＜0.0001;病程SMD=-0.17,95％CI(-1.09,0.75),P=0.71;性别RR=1.06,95％CI(1.00,1.12),P=0.05;中轴或外周关节首发RR=0.42,95％CI(0.22,0.80),P=0.009和RR=1.28,95％CI(1.02,1.60),P=0.03;髋关节和腰骶痛起病RR=1.49,95％CI(0.99,2.24),P=0.06和RR=0.96,95％CI(0.90,1.02),P=0.16;幼年起病RR=1.94,95％CI(1.21,3.11),P=0.006;外周关节炎RR=1.92,95％CI(1.57,2.36),P＜0.00001;家族史RR=2.76,95％CI(1.81,4.20),P＜0.00001;HLA-B27RR=1.02,95％CI(0.93,1.13),P=0.66,ESR SMD=0.32,95％CI(-0.42,1.05),P=0.40;CRP SMD=0.37,95％C1(-0.25,1.00),P=0.24;BASDAISMD=0.11,95％C1(-0.09,0.30),P=0.28;BASFI SMD=0.74,95％CI(0.54,0.93),P＜0.00001;骶髂关节炎RR=1.28,95％CI(0.84,1.72),P＜0.00001. 结论：发病年龄、幼年起病、性别、中轴或外周症状为首发表现、家族史、BASFI及骶髂关节炎是强直性脊柱炎髋关节病变的危险因素.