Klinefelter syndrome (KS) is inherited infertility with male chromosome aneuploidy, but its pathophysiology remain unclear due to lack of an adequate model. We have set up induced pluripotent stem cells (iPSC) from KS patient with a karyotype of 47, XXY. Here, we report the KS-iPSC can differentiated into primordial germ cells(PGC) and spermatogonial stem cells(SSC), but is blocked in the meiosis stage with increasing cell apoptosis due to chromosome aneuploidy. So, we could enhance the ability of differentiating into haploid cells of KS-iPS by overexpressing the proteins associated with meiosis. The study maybe opens a new avenue for the understanding and treatment of KS.
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