Delivery and penetration of chemotherapeutic drugs into neoplasm through the tumor vasculature are essential mechanisms to enhance the effieiency of chemotherapy."Vascular targeting"strategy focuses on promoting the infiltration of chemotherapeutic drugs into neoplastic tissues.In this study, we achieved a targeted therapy by coupling tumor necrosis factor a (TNFa) with TCP-1, a novel vascular-targeting peptide, in an orthotopic colorectal cancer model in mice. High dose of TCP-1-conjugated TNFa (TCP-1/TNFa: 5ug/mouse) displayed potent antitumor activity by inducing apoptosis and reducing microvessel number in tumors than unconjugated TNFa, with no evidence of increased toxicity.
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