Recent study showed that a method for gene therapy by using ribozyme(Rz) had broad application prospects and great clinical practical value.However, there was little information available in literature about its application on schistosomiasis.The aim of this study was to construct the systems of hammerhead ribozymes targeting to the eggshell protein gene of Schistosoma japonicum (SjESG)and to test their cleavage activity in vitro and anti-reproduction contribution on Schistosoma japonicum (S.japonicum) in vivo. These findings showed the system ofhammerhead ribozymes against SjESG had contribution to anti-reproduction on S.japonicumin the BABL/c mice infected by cercariaes.
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