Objective： Mesenchymal stem cells (MSCs) can be induced to differentiate into neuronal cells underappropriate cellular conditions and transplanted in brain injury and neurodegenerative diseases animalmodels for neurorestoratology studies. In contrast to the embryonic stem cells (ESCs), MSCs are easilysubject to aging and senescence because of their finite ability of self-renewal. MSCs senescence seriouslyaffected theirs application prospectsas a promising tool for cell-based regenerativemedicine and tissueengineering. In the present study, we establish a reversibleimmortalized mesenchymal stem cells (IMSCs)line by using SSR#69 retrovirus expressing simian virus 40 large T (SV40T) antigen to solve these problemsof MSCs.
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