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移植,同种

移植,同种的相关文献在1989年到2021年内共计483篇,主要集中在外科学、基础医学、内科学 等领域,其中期刊论文481篇、专利文献9548篇;相关期刊109种,包括医学临床研究、中国骨科临床与基础研究杂志、中华创伤杂志等; 移植,同种的相关文献由1944位作者贡献,包括裴国献、郑小飞、顾立强等。

移植,同种—发文量

期刊论文>

论文:481 占比:4.80%

专利文献>

论文:9548 占比:95.20%

总计:10029篇

移植,同种—发文趋势图

移植,同种

-研究学者

  • 裴国献
  • 郑小飞
  • 顾立强
  • 朱立军
  • 衷鸿宾
  • 侯树勋
  • 卢世璧
  • 刘迎龙
  • 张伟杰
  • 张信英
  • 期刊论文
  • 专利文献

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    • 程木举; 武竞衡; 张有乐; 李文军
    • 摘要: 目的分析应用同种异体肌腱修复手部伸指(拇)肌腱断裂的的短期随访结果。方法2019年10月至2020年9月北京积水潭医院手外科收治自发性伸指(拇)肌腱断裂患者共18例;男9例,女9例;平均年龄59.2(29~86)岁。手术均采用同种异体肌腱移植修复,原动力重建伸指(拇)功能。术后石膏固定于伸指(拇)功能位4周,拆除石膏后开始在医师指导下主动功能锻炼2周。术后6周后逐渐进行负重锻炼。本组18例平均随访8.1(3~12)个月。结果所有患者手术切口均为I期愈合,无炎性反应,无免疫排斥反应,无肌腱再次断裂的病例。根据主动活动度系统评定方法优11例,良3例,可3例,差1例。功能差1例为术后出现严重的肌腱粘连,4个月后再次行肌腱松解手术,达到满意效果。结论同种异体肌腱作为移植物对修复自发性伸肌腱断裂,短期随访观察到患者已取得了满意的临床疗效。这项技术可逐渐广泛地应用到肌腱修复的临床治疗。
    • 程木举; 武竞衡; 张有乐; 李文军
    • 摘要: 目的 分析应用同种异体肌腱修复手部伸指(拇)肌腱断裂的的短期随访结果.方法 2019年10月至2020年9月北京积水潭医院手外科收治自发性伸指(拇)肌腱断裂患者共18例;男9例,女9例;平均年龄59.2(29~86)岁.手术均采用同种异体肌腱移植修复,原动力重建伸指(拇)功能.术后石膏固定于伸指(拇)功能位4周,拆除石膏后开始在医师指导下主动功能锻炼2周.术后6周后逐渐进行负重锻炼.本组18例平均随访8.1(3~12)个月.结果 所有患者手术切口均为I期愈合,无炎性反应,无免疫排斥反应,无肌腱再次断裂的病例.根据主动活动度系统评定方法:优11例,良3例,可3例,差1例.功能差1例为术后出现严重的肌腱粘连,4个月后再次行肌腱松解手术,达到满意效果.结论 同种异体肌腱作为移植物对修复自发性伸肌腱断裂,短期随访观察到患者已取得了满意的临床疗效.这项技术可逐渐广泛地应用到肌腱修复的临床治疗.
    • 洪郭驹
    • 摘要: 同种异体软骨移植是治疗关节软骨缺损的有效手段,可解决自体骨软骨来源有限的问题,但如何长期保存同种异体软骨是亟待解决的问题。区别于主流的低温冷冻同种异体软骨的方法,超低温冷冻技术在添加冷冻保护剂情况下,预期可以实现同种异体软骨的长期保存。然而,此技术目前仍处于探索阶段,缺乏成熟的临床转化条件。本文介绍了同种异体软骨的超低温冷冻法,着重阐述了超低温冷冻法中的玻璃化冷冻技术,并重点综述了超低温冷冻同种异体软骨的临床应用。
    • 陈焕伟; 栾晓军; 刘成洋; 肖平; 陈劲松; 王晓洲; 邓斐文; 刘颖; 陈国强
    • 摘要: 目的 探讨同种异体胰岛细胞移植治疗成人1型糖尿病的疗效及安全性.方法 回顾性分析2018年12月佛山市第一人民医院行同种异体胰岛细胞移植术的1例1型糖尿病受者临床资料.供受者和(或)家属均签署知情同意书,符合医学伦理学规定.受者男,54岁.供者男,37岁,心脏死亡器官捐献,器官捐赠时血糖水平正常.供受者ABO血型相同,人类白细胞抗原(HLA)配型良好,群体反应性抗体(PRA)为阴性,热缺血时间5 min,冷缺血时间210 min.采用标准的腹部多器官联合快速切取技术获取胰腺,在胰岛分离实验室分离纯化获得的胰岛细胞,移植培养基中培养24 h,胰岛细胞质量、数量及内毒素监测合格后在数字减影血管造影(DSA)下通过彩超引导经皮经肝门静脉穿刺置管将胰岛细胞悬液输注受者肝脏门静脉系统内.受者同时接受免疫抑制药物治疗,术后定期监测血糖、C肽、血清胰岛素浓度及免疫抑制剂浓度,观察围手术期并发症.结果 供者胰腺成功分离胰岛细胞,胰岛细胞数量为21×104 IEQ,纯度为70%,活率>90%.受者接受胰岛移植后血糖水平逐渐恢复稳定,血糖脆性得到改善,空腹及刺激后C肽水平较前升高,外源性胰岛素用量较移植前明显减少.受者围手术期出现畏寒、发热,给予静脉滴注甲基强的松龙后缓解.未出现酮症酸中毒及低血糖反应,未发生急性排斥反应、感染等并发症.截止投稿日期,受者胰岛素日总剂量减少78%,从49 U/d减到11 U/d,且血糖控制更平稳.结论 同种异体胰岛细胞移植治疗成人1型糖尿病是安全、有效的.
    • 韩巍; 张腾; 王军强; 黄强; 吴新宝
    • 摘要: 目的探讨应用同种异体腓骨移植联合锁定加压钢板固定治疗老年粉碎性肱骨近端骨折的临床疗效。方法回顾分析2015年1月至2018年12月北京积水潭医院创伤骨科收治的老年粉碎性(Neer 3部分及4部分)肱骨近端骨折患者53例临床资料。其中男6例,女47例,年龄(72.7±4.8)(65~84)岁。受伤机制包括摔伤48例,交通事故伤4例,高处坠落伤1例。根据手术方式分为同种异体腓骨移植联合锁定加压钢板固定组(简称移植组,n=36)和人工肱骨头置换组(简称置换组,n=17)。记录两组患者受伤至手术时间、手术时间、术中出血量与术后住院时间并进行比较。记录两组患者末次随访疼痛视觉模拟评分(VAS),美国加州大学肩关节功能评分(UCLA)、Constant-Murley肩关节功能评分及评分分级等指标并进行比较。结果53例患者均顺利完成手术。移植组患者手术时间及术后住院时间少于置换组(P=0.002,0.003);两组患者术中出血量差异无统计学意义。术后所有患者未出现切口及深部感染以及手术相关的神经血管损伤,骨折均获得骨性愈合,未见延迟愈合、内固定失效及再骨折。移植组3例患者出现术后肱骨头坏死,患者自觉症状轻,未行人工肩关节置换术。两组患者VAS评分差异无统计学意义;移植组患者UCLA评分与Constant-Murley评分均高于置换组(P=0.002,<0.001);移植组患者Constant-Murley评分中日常活动与活动范围评分均高于置换组(P=0.003,0.002);两组患者肌力差异无统计学意义。结论同种异体腓骨移植联合锁定加压钢板固定治疗老年粉碎性肱骨近端骨折安全有效,与人工肱骨头置换术相比,可减少手术时间及术后住院时间,同时获得更好的肩关节功能,但存在肱骨头坏死的风险。
    • 陈娟; 冯四洲
    • 摘要: 巨细胞病毒(CMV)感染是异基因造血干细胞移植(allo-HSCT)后的常见并发症.allo-HSCT后CMV感染患者的主要临床表现为肺部感染,胃、肠道炎症,脑炎,肝炎,视网膜炎及无症状CMV血症等.CMV感染还可影响患者的免疫功能,增加细菌、真菌等病原菌感染风险,以及移植物抗宿主病(GVHD)和骨髓衰竭的发生风险.近年来,由于对allo-HSCT后患者预防性使用抗病毒药物,其CMV感染发生率有所下降.然而,多药耐药的出现及复发/难治性CMV感染,仍然严重影响allo-HSCT患者预后.笔者拟就allo-HSCT后CMV感染的危险因素、检测与诊断方法、预防及治疗等方面进行阐述,旨在为allo-HSCT后CMV感染的防治提供新思路.
    • 洪郭驹; 韩晓蕊
    • 摘要: 同种异体软骨移植作为一种新兴的治疗方法,主要用于重建关节中的软骨结构。低温保存技术作为该疗法实施过程中的一项关键技术,可以保持同种异体软骨结构完整及软骨细胞活性直至移植,低温保存介质、低温保存的时间及移植软骨的体积等因素均会对同种异体软骨低温保存的效果产生影响,最终影响同种异体软骨移植的疗效。本文从同种异体软骨组织低温保存技术的应用现状和同种异体软骨低温保存的影响因素2个方面对该技术的研究进展进行了综述。
    • 徐玥; 李卫平; 江川; 张正政; 周云烽; 罗焕; 张昊智; 宋斌
    • 摘要: Objective To compare the clinical effects of autologous semitendinosus tendon and allogenic tendon arthroscopic anatomical reconstruction of anterior talofibular ligament (ATFL) combined with calcaneofibular ligament (CFL) in the treatment of chronic lateral ankle instability.Methods A retrospective analysis was made of 55 patients with chronic lateral ankle instability who underwent arthroscopic reconstruction of ATFL combined with CFL from January 2012 to June 2017.A total of 28 cases were treated with autologous semitendinosus tendon (autologous group),including 19 males and 9 females,with an average age of 28.5±8.03 years (range,16-46 years).A total of 27 cases were treated with allogenic tendon (allogenic group),including 17 males and 10 females,with an average age of 27.48±7.89 years (range,16-46 years).ATFL/CFL was reconstructed by the same method in both groups.The reconstruction methods were the same between the groups.The talus and calcaneus were fixed with absorbable compression nails.Results The operation duration in the autologous group was 94.07±7.83 min,which was longer than that in the allogeneic group 63.56±7.96 min (t=14.51,P<0.001).Fever days 5.26±0.90 days in allogeneic group were longer than 2.46±0.74 days in autologous group (t=-12.55,P<0.001).Wound healing duration in allogeneic group was 13.44±3.33 days longer than that in autologous group 10.32±2.34 days (t=-4.01,P<0.001).In the autologous group,28 cases were followed up for 34.54± 16.04 months,and 27 cases in the allograft group were followed up for 42.74± 17.79 months.The mean AOFAS score improved from 63.64± 11.20 before operation to 90.21 ±4.48 after operation in the autologous group,and that improved from 63.93± 10.59 before operation to 89.56±5.15 after operation in the allogeneic group with no significant difference between the two groups after operation (t=0.506,P=0.615).The mean VAS score decreased from 5.79± 1.79 before operation to 1.54± 1.35 after operation in the autologous group,and from 5.89± 1.78 before operation to 2.04± 1.32 after operation in the allogeneic group.There was no significant difference between the two groups after operation (t=-1.396,P=0.168).Tegner score increased from 4.07± 1.39 to 6.43± 1.14 in the autologous group and from 3.85±1.06 to 6.52±0.85 in the allogeneic group with no significant difference between the two groups after operation (t=-0.333,P=0.740).Stress radiographic showed that the talar tilt angle decreased from 15.60°±3.86° to 6.01°±2.64° in the autologous group,16.99°±3.78° to 7.14°±3.34° in the allogeneic group,and there was no significant difference between the two groups after operation (t=-1.382,P=0.171).Anterior talar displacement reduced from 10.82±3.12 mm to 4.03±1.69 mm in the autologous group,from 10.10±2.02 mm to 4.17±1.52 mm in the allogeneic group,and there was no significant difference between the two groups after operation (t=-0.326,P=0.746).No donor tendon dysfunction was found in the autologous group.At the end of follow-up,there was no difference in ankle dorsiflexion,plantar flexion and hind foot mobility between autologous group and allogeneic group.Conclusion Arthroscopic autologous tendon and allogeneic tendon reconstruction of AFTL combined with CFL can obtain satisfactory short-term results.The autologous tendon group was superior to the allogeneic group in terms of fever,wound healing time.However,there was no significant difference in clinical effects between the two groups.%目的 探讨关节镜下自体半腱肌肌腱与同种异体肌腱解剖重建距腓前韧带联合跟腓韧带治疗慢性踝关节外侧不稳的临床疗效.方法 回顾性分析2012年1月至2017年6月采用关节镜下距腓前韧带联合跟腓韧带重建的慢性踝关节外侧不稳患者55例.术中采用自体半腱肌腱重建(自体组)28例,男19例、女9例,年龄(28.5±8.03)岁(范围16~46岁);采用同种异体肌腱重建(异体组)27例,男17例、女10例,年龄(27.48±7.89)岁(范围16~46岁).重建方法相同,距骨端及跟骨端均采用可吸收挤压螺钉固定.结果 自体组手术时间(94.07±7.83) min,长于异体组的(63.56±7.96) min(t=14.51,P<0.001);异体组术后发热时间为(5.26±0.90)d,长于自体组的(2.46±0.74) d(t=-12.55,P<0.001);异体组伤口愈合时间为(13.44土3.33)d,长于自体组的(10.32±2.34)d(t=-4.01,P<0.001).自体组随访(34.54±16.04)个月,异体组随访(42.74±17.79)个月.末次随访时,自体组美国足踝外科协会(American Orthopaedic Foot and Ankle Society,AOFAS)踝与后足评分由术前(63.64±11.20)分提高至(90.21±4.48)分,异体组由术前(63.93±10.59)分提高至(89.56±5.15)分,术后两组差异无统计学意义(t=0.506,P=0.615);自体组视觉模拟评分(visual analogue scale,VAS)由术前(5.79±1.79)分降低至(1.54±1.35)分,异体组由术前(5.89±1.78)分降低至(2.04±1.32)分,术后两组差异无统计学意义(t=-1.396,P=0.168);自体组Teg-ner运动水平评分由术前(4.07±1.39)分提高至(6.43±1.14)分,异体组由(3.85±1.06)分提高至(6.52±0.85)分,术后两组差异无统计学意义(t=-0.333,P=0.740);自体组应力位X线片上距骨倾斜角由术前15.60°±3.86°减少至6.01°土2.64°,异体组由16.99°±3.78°减少至7.14°±3.34°,术后两组差异无统计学意义(t=-1.382,P=0.171);自体组距骨前移距离由(10.82±3.12)mm减少至(4.03±1.69) mm,异体组由(10.10±2.02) mm减少至(4.17±1.52) mm,术后两组差异无统计学意义(t=-0.326,P=0.746).自体组无一例发生膝部肌腱供区功能障碍.末次随访时所有患者患侧与健侧的踝关节背伸、跖屈活动度、后足活动度的差异均无统计学意义.结论 关节镜下自体肌腱或同种异体肌腱移植重建距腓前韧带联合跟腓韧带均可取得较为满意的近期疗效,自体肌腱移植在发热、伤口愈合时间方面优于异体肌腱移植,但临床疗效并无明显差异.
    • 刘鹏飞; 段显琳; 江明
    • 摘要: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been widely used in the treatment of hematologic discases and other malignant solid tumors.However,there are also a series of problems after allo-HSCT,such as the recurrence of the primary disease,graft rejection (GR),graft versus host disease(GVHD) and so on,which may lead to the failure of transplantation,and are currently important problems affecting the efficacy of allo-HSCT.Dynamic monitoring of chimeric state of donor and recipient cells and timely corresponding clinical treatment have great significance to reduce the recurrence of disease,GR and GVHD.The chimeric state of T cells is related to the occurrence of GVHD after transplantation,and the higher the chimeric rate of T cells in the early stage,the more likely GVHD will occur.The chimeric state of B cells is often correlated with the recurrence after transplantation.In this paper,the clinical significance of dynamic monitoring of chimeric rate of patients after allo-HSCT was elaborated from the monitoring of chimeric rate of different immune cell subgroups and the factors influencing chimeric state,so as to further guide clinical treatment and intervention.%目前,异基因造血干细胞移植(allo-HSCT)已被越来越广泛地应用于血液系统疾病及恶性实体肿瘤等的治疗.但患者接受allo-HSCT后亦存在一系列问题,如原发病复发、移植物排斥(GR)、移植物抗宿主病(GVHD)等,这可能导致移植失败,亦是目前影响allo-HSCT疗效的重要难题.动态监测供、受者不同免疫细胞亚群的嵌合状态,并且及时作出相应的临床处理,对减少疾病复发和GR,降低GVHD发生风险有重要意义.其中,T细胞的嵌合状态与移植后GVHD发生相关,患者移植早期的T细胞嵌合率越高,则越容易发生GVHD;B细胞的嵌合状态通常与allo-HSCT后复发有相关性.笔者主要就不同免疫细胞亚群嵌合率的监测,结合影响嵌合状态的因素,对动态监测嵌合率在allo-HSCT后的临床意义进行综述,从而进一步指导临床治疗和干预.
    • 葛鸿庆; 郑沐欣; 管华
    • 摘要: 目的 探讨锁定钢板联合同种异体腓骨髓内支撑治疗老年内翻型肱骨近端骨折的临床疗效. 方法 回顾性分析2015年5月至2017年7月广州中医药大学第二临床医学院骨科采用锁定钢板联合同种异体腓骨髓内支撑技术治疗21例老年内翻型肱骨近端骨折患者资料.男6例,女15例;年龄65 ~ 90岁,平均74.8岁;其中Neer二部分骨折2例,三部分骨折14例,四部分骨折5例.记录患者的手术时间、术中出血量、术后并发症及末次随访时功能评分,比较术前及术后、末次随访时肱骨颈干角及肱骨头高度的变化. 结果手术时间70 ~ 110 min,平均89.5 min;术中出血量160 ~400 mL,平均179.5 mL.21例患者术后获12 ~ 26个月(平均18.1个月)随访,伤口皆一期愈合,1例患者发生螺钉穿出,无神经、血管损伤、肩关节脱位、肱骨头坏死等并发症发生.末次随访时按Neer's肩关节功能评分系统评定疗效:优3例,良15例,可3例,优良率为85.7%.术后初次摄X线片颈干角为136.4°±5.8°,与术前颈干角(106.0°±7.3°)相比差异具有统计学意义(P<0.05),与末次随访时颈干角(135.4°土6.5°)相比,差异无统计学意义(P>0.05).术后初次摄片时钢板最上缘和肱骨头最上缘之间的距离为(1.6±0.2) mm,末次随访时为(1.54±0.22) mm,差异无统计学意义(P>0.05). 结论采用锁定钢板联合异体腓骨髓内支撑技术可有效重建肱骨近端内侧柱,恢复颈干角,并且术中可以辅助复位、减少手术时间,术后可获得良好的肩关节功能,避免相关并发症的发生.%Objective To evaluate the clinical outcomes of locking plate combined with allogenic fibular intramedullary support in the elderly patients with varus proximal humeral fracture.Methods From May 2015 to July 2017,21 elderly patients with varus proximal humeral fracture were treated with locking plate combined with allogenic fibular intramedullary support at Department of Orthopaedics,The Second Clinical Medical College,Guangzhou University of Traditional Chinese Medicine.They were 6 men and 15 women,from 65 to 90 years of age (average,74.8 years).According to the Neer classification,2-part fracture was identified in 2 patients,3-part fracture in 14 and 4-part fracture in 5.Their operation time,amount of intraoperative bleeding,postoperative complications and functional scores at the last follow-up were recorded.The humeral neck angles and humeral head heights were compared between preoperation,postoperation and the last follow-up.Results Their operation time averaged 89.5 minutes (from 70 to 110 minutes) and intraoperative bleeding 179.5 mL (from 160 to 400 mL).They obtained follow-up from 12 to 26 months (average,18.1months).All the wounds were healed by the first intention.No such complications occurred as neurovascular lesion,shoulder dislocation or humeral head necrosis.However,screw cut-out was observed in one case.According to the Neer's scoring system,shoulder function was evaluated at the last follow-up as excellent in 3cases,as good in 15 and as fair in 3,giving a good to excellent rate of 85.7%.The humeral neck angle after operation was 136.4° ± 5.8°,significantly larger than the preoperative one (106.0° ± 7.3°) (P <0.05) but insignificantly different from the value at the last follow-up (135.4° ±6.5°) (P > 0.05).The postoperative distance between the plate top and the humeral head top was 1.6± 0.2 mm,insignificantly different from that at the last follow-up (1.5 ± 0.2 mm) (P > 0.05).Conclusion Locking plate combined with allogenic fibular intramedullary support can effectively reconstruct the medial proximal column of the humerus,restore the humeral neck angle,facilitate intraoperative fracture reposition and reduce operation time,leading to good functional recovery of the shoulder and prevention of related complications.
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