Leptin/leptinR-kisspeptin/kiss1r-GnRH pathway reacting to regulate puberty onset during negative energy balance

摘要

Aims: Reproductive endocrine disorder induced by negative energy balance is very common in recent years. But underlying mechanism of reproductive disorders still remains elusive. It is reported that leptin/leptinR-kisspeptin/kiss1r system plays a critical role in reproductive field. Therefore, this study was to determine the role of leptin/leptinR in the expression of kisspeptin/kiss1r during negative energy balance and effect of leptin/leptinR-kisspeptin/kiss1r on puberty onset.