FULL-HUMAN BROAD-SPECTRUM CROSS-NEUTRALIZING ANTIBODY FOR SARS-COV-2 AND SARS-COV AND APPLICATION THEREOF

摘要

A broad-spectrum cross-neutralizing antibody for coronaviruses SARS-CoV-2 and SARS-CoV and an application thereof. Specifically, the present invention relates to multiple strains of full-human monoclonal antibodies targeting an RBD protein of novel coronaviruses SARS-CoV-2 and SARS-CoV, a nucleic acid sequence encoding an antibody and an antibody fragment, and a preparation method therefor. In-vitro experiments prove that the antibody can effectively inhibit the infection of SARS-CoV-2 and SARS-CoV pseudo viruses and SARS-CoV-2 eukaryotic virus to host cells, and play a neutralizing role by means of different mechanisms, thereby effectively preventing and controlling coronavirus infection and reducing the incidence of drug resistance.