PRODUCTION METHOD FOR NON-HUMAN MODEL ANIMAL WITH MENTAL DISORDER OR NEUROLOGICAL DISORDER, SAID NON-HUMAN MODEL ANIMAL, AND METHOD FOR SCREENING FOR PROPHYLACTIC OR THERAPEUTIC AGENT FOR SAID MENTAL DISORDER OR NEUROLOGICAL DISORDER

摘要

Provided are: a method for producing a non-human model animal with a mental disorder or neurological disorder that is attributed to an increase or decrease in the expression of an AMPA receptor gene or an increase or decrease in the expression or function of an AMPA receptor in a predetermined region in the brain; a non-human model animal with the mental disorder or neurological disorder; and a screening method for discovering a prophylactic or therapeutic agent for the mental disorder or neurological disorder, using the non-human model animal.　This method is for producing a non-human model animal with a mental disorder or neurological disorder that is attributed to an increase or decrease in the expression of an AMPA receptor gene or an increase or decrease in the expression or function of an AMPA receptor in a predetermined region in the brain. The method comprises: a step for decreasing or increasing at least one selected from the group consisting of the expression of the AMPA receptor gene or the AMPA receptor, and the function of the AMPA receptor, in the predetermined region of the non-human animal, compared to a wild type, or a step for inhibiting or activating a nervous pathway connecting the predetermined region with another region.