TREATMENT OF GASTROINTESTINAL BLEEDING IN PATIENTS WITH SEVERE VON WILLEBRAND DISEASE BY ADMINISTRATION OF RECOMBINANT vWF

摘要

FIELD: biotechnology; medicine.;SUBSTANCE: invention relates to biotechnology and medicine, in particular to a method for the treatment of gastrointestinal bleeding in a subject with severe von Willebrand disease, including the administration to the subject of at least one dose of recombinant von Willebrand factor (rvWF) in the range from about 40 IU/kg to about 100 IU/kg, while the first dose additionally contains recombinant factor VIII (rFVIII). ;EFFECT: invention makes it possible to effectively treat gastrointestinal bleeding in a subject with a severe form of von Willebrand disease.;19 cl, 2 dwg, 218 tbl, 2 ex