Method for determining possibility of cell-fate according to drug dosage amount dose and device for the same

摘要

As a model of the cell's biosignal transduction method, a cell death probability calculation method that calculates the cell death probability according to the perturbation probability of a specific perturbation target node of the Boolean network whose state transition equation is determined is disclosed. For one initial state value or each of a plurality of initial state values that the Boolean network may have, the state value of the Boolean network is transitioned according to the state transition equation of the Boolean network to obtain a plurality of state values. In the state value acquisition step of acquiring an average calculation step of calculating an average value for at least a portion of the state values, and a ratio determining step of determining a ratio of the average values having a value equal to or greater than a predetermined threshold value among a plurality of the average values obtained in the average calculation step . The state value of the first perturbation node of the Boolean network is fixed to a value indicating the deactivation of the first perturbation node with a predetermined probability of x1%, and the first perturbation node with a probability of (100-x1)% It is determined according to the state transition equation that determines the transition of the state value of the node.