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AUTO/ALLOIMMUNE PROTECTION RECEPTORS FOR SELECTIVE TARGETING OF ACTIVATED PATHOGENIC T-CELLS AND NK-CELLS
AUTO/ALLOIMMUNE PROTECTION RECEPTORS FOR SELECTIVE TARGETING OF ACTIVATED PATHOGENIC T-CELLS AND NK-CELLS
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机译:自动/受体选择性同种免疫的保护针对致病性t细胞激活的NK-CELLS
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摘要
Embodiments of the disclosure concern engineered auto/allo-immune defense receptor (ADR)-expressing T cells that selectively target activated T cells, including pathogenic T cells, to incapacitate them. The chimeric receptors comprise moieties for targeting 4-1BB, 0X40, and CD40L, for example, whose expression is indicative of activated T cells. In particular embodiments, there are methods of preventing or treating conditions associated with activated T cells using adoptive T-cell transfer of cells encoding the ADRs.
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